Research Articles
Structural Insights into STAT SH2 Domain-Phosphopeptide Complexes: From Crystallography to Drug Discovery
This article provides a comprehensive analysis of the crystallography of STAT SH2 domain-phosphopeptide complexes, crucial for understanding cell signaling and developing targeted therapies.
Isothermal Titration Calorimetry (ITC): A Comprehensive Guide for Measuring STAT SH2 Domain Binding Affinity in Drug Discovery
This article provides a comprehensive resource for researchers and drug development professionals on the application of Isothermal Titration Calorimetry (ITC) for characterizing binding interactions with STAT SH2 domains.
Advanced Virtual Screening Strategies for STAT SH2 Domain Inhibitors: From Ultra-Large Libraries to Clinical Translation
This article provides a comprehensive overview of contemporary virtual screening (VS) strategies specifically tailored for identifying inhibitors of STAT protein SH2 domains, challenging targets in oncology drug discovery.
Targeting the SH2 Domain: Strategic Inhibition of STAT Dimerization for Cancer Therapeutics
This article provides a comprehensive analysis of the Src Homology 2 (SH2) domain as a critical therapeutic target for inhibiting Signal Transducer and Activator of Transcription (STAT) dimerization, a key...
Structural Divergence in SH2 Domains: Decoding STAT-type vs. Src-type for Targeted Therapeutics
This article provides a comprehensive analysis of the structural distinctions between STAT-type and Src-type Src Homology 2 (SH2) domains, modular protein domains critical for phosphotyrosine signaling.
The SH2 Domain Gateway: Orchestrating STAT Protein Nuclear Translocation and DNA Binding for Therapeutic Targeting
This article provides a comprehensive analysis of the critical role Src Homology 2 (SH2) domains play in the activation, nuclear translocation, and DNA binding of Signal Transducer and Activator of...
Beyond Dimerization: Exploring Non-Canonical STAT Functions Independent of the SH2 Domain
This article synthesizes current research on non-canonical STAT signaling, which operates independently of the canonical SH2 domain-mediated phosphotyrosine dimerization.
Decoding STAT SH2 Domains: Mechanisms of Phosphotyrosine Recognition and Therapeutic Targeting
This article provides a comprehensive overview of the structural and functional mechanisms governing phosphotyrosine recognition by STAT SH2 domains, crucial elements in JAK-STAT signaling.
Dynamic Targeting: How STAT SH2 Domain Flexibility is Reshaping Drug Discovery
This article provides a comprehensive exploration of the molecular dynamics and conformational flexibility of STAT SH2 domains, a critical target in oncology and immunology.
STAT SH2 Domain Mutations: Molecular Mechanisms, Disease Pathogenesis, and Therapeutic Opportunities
This article provides a comprehensive analysis of Src Homology 2 (SH2) domain mutations within STAT (Signal Transducer and Activator of Transcription) proteins and their profound implications in human disease.