Research Articles
NDR Kinase Phosphorylation of p21: Mechanisms, Methods, and Therapeutic Implications for Protein Stability Regulation
This article provides a comprehensive analysis of the post-translational regulation of the cyclin-dependent kinase inhibitor p21 by NDR kinase phosphorylation.
siRNA-Mediated Knockdown of NDR1/2: Mechanisms and Implications for Cell Proliferation in Cancer and Beyond
This article comprehensively explores the critical roles of NDR1 and NDR2 kinases in regulating cell proliferation and the consequential effects of their siRNA-mediated knockdown.
Identifying MOB2 Binding Partners: A Comprehensive Guide to Yeast Two-Hybrid Screening
This article provides a detailed methodological and conceptual framework for using yeast two-hybrid (Y2H) screening to identify and characterize binding partners of the MOB2 protein, a key adaptor in Hippo...
Detecting MOB-NDR Protein Interactions: A Comprehensive Guide to Co-Immunoprecipitation Methods and Applications
This article provides a comprehensive resource for researchers studying the critical interactions between MOB scaffold proteins and NDR/LATS kinases, with a focused guide on Co-Immunoprecipitation (Co-IP) methodologies.
NDR1/2 Kinases in Centrosome Duplication: Regulatory Mechanisms and Therapeutic Implications
This article provides a comprehensive review of the established and emerging roles of NDR1/2 kinases in the critical process of centrosome duplication.
Activation and Analysis of Human NDR1/2 Kinases: A Comprehensive Guide to MOB1-Dependent Activity Assays
This article provides a comprehensive resource for researchers and drug development professionals on conducting and interpreting NDR1/2 kinase activity assays with the essential co-activator MOB1.
MOB2 and RAD50: Unveiling a Novel Partnership in DNA Damage Signaling and Cancer
This article synthesizes current research on the critical interaction between MOB2 and the RAD50 component of the MRN complex, a cornerstone of the DNA damage response (DDR).
MOB1 vs MOB2: Decoding Binding Specificity and Functional Regulation of NDR Kinases in Hippo Signaling
This article provides a comprehensive analysis of the distinct binding specificities of MOB1 and MOB2 coactivators for NDR/LATS kinases, crucial regulators in Hippo signaling pathways.
Decoding the G1/S Checkpoint: How NDR1/2 Kinases Govern Cell Cycle Progression and Offer Novel Cancer Therapeutic Avenues
This article provides a comprehensive analysis of the mechanism by which NDR1 and NDR2 kinases regulate the critical G1/S phase transition in the mammalian cell cycle.
MOB2 as a Key Inhibitory Regulator of NDR1/2 Kinase Activity: Mechanisms and Therapeutic Implications
This article provides a comprehensive analysis of the molecular mechanism by which the Mps one binder 2 (MOB2) protein inhibits the NDR1/2 (STK38/STK38L) kinases.